The structure modification of seven-membered aza-brigded neonicotinoids in order to investigate their impact on honey bees

In order to explore the relationship between structure and toxicity honey bees of seven-membered aza-bridged neonicotinoids, 16 novel neonicotinoid analogues are synthesized by replacing pyridine ring, changing substituents on electron-withdrawing group NO 2 imidazole ring our previously developed 1-[(6-chloropyridin-3-yl)methyl)]-10-(2,5-dimethylphenyl)-9-nitro-2,3,5,6,7,8-hexahydro-1 H-5,8-epiminoimidazo azepine (C-29). The insecticidal bioactivities against cowpea aphid ( Aphis craccivora) bee toxicities these compounds tested. Some title present good activities aphid. results also show that some exhibit lower than C-29 imidacloprid. This suggests neonicotinoids can influence toward analogues.